» Published on
16. Mai 2018
Tailor-made synthesis of cyclic chemicals by means of enzymes
Bielefeld chemists publish research article in the journal “Nature Communications”
Penicillin-based
antibiotics contain a five-membered hydrocarbon cycle, additionally
incorporating a sulfur and a nitrogen atom. Nadine Zumbrägel, doctoral
student at the Chair of Organic Chemistry I at Bielefeld University, has
succeeded in selectively synthesizing this important substructure with
different residues on this cycle using a biotechnological method. The
targeted design of such structures now enables the preparation of
substance libraries of such so-called heterocycles, which can in future
be used by the pharmaceutical industry to find new active substances.
Besides the Bielefeld chemists, two scientists from the Ruhr-University
Bochum were also involved in the studies. The researchers present their
findings today (16 May 2018) in the renowned journal “Nature
Communications” with Zumbrägel as first author and Professor Dr. Harald
Gröger, head of the Chair of Organic Chemistry I, as corresponding
author.
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