Einladung zum Gastvortrag
Veröffentlicht am 22. Juni 2023, 14:17 Uhr
Wir laden Sie am
30.06.2023, von 14.00 – 15.00 Uhr, zu einem Gastvortrag an der
Medizinischen Fakultät ein.
Titel: Illuminating the action of mechanosensitive adhesion GPCRs
Vortragender: Prof. Dr. Tobias Langenhan, Leipzig University, Rudolf Schönheimer Institute of Biochemistry
Gastgeber: Prof. Dr. Erhard Wischmeyer, Med. Fak. OWL, AG 8 Zelluläre Neurophysiologie
Veranstaltungsort: Gebäude R.1, Konferenzraum Z3, Morgenbreede 1, 33615 Bielefeld
Abstract
G protein coupled receptors (GPCR) have proven a treasure trove for modern pharmacological intervention of numerous human ailments. However, in stark contrast to classically targeted GPCRs, adhesion GPCRs have been largely neglected by biologists, pharmacologists and clinician scientists for decades. Only recently their physiological and signaling properties are being unraveled and show exciting features including their roles in tissue architecture, signaling through tethered agonism, cell-autonomous and non-autonomous effects, and their unusual activation through mechanical cues. I will discuss the recent developments on adhesion GPCR signaling and introduce the receptor family as a topical area in neuroscience, immunology and cancer research.
Titel: Illuminating the action of mechanosensitive adhesion GPCRs
Vortragender: Prof. Dr. Tobias Langenhan, Leipzig University, Rudolf Schönheimer Institute of Biochemistry
Gastgeber: Prof. Dr. Erhard Wischmeyer, Med. Fak. OWL, AG 8 Zelluläre Neurophysiologie
Veranstaltungsort: Gebäude R.1, Konferenzraum Z3, Morgenbreede 1, 33615 Bielefeld
Abstract
G protein coupled receptors (GPCR) have proven a treasure trove for modern pharmacological intervention of numerous human ailments. However, in stark contrast to classically targeted GPCRs, adhesion GPCRs have been largely neglected by biologists, pharmacologists and clinician scientists for decades. Only recently their physiological and signaling properties are being unraveled and show exciting features including their roles in tissue architecture, signaling through tethered agonism, cell-autonomous and non-autonomous effects, and their unusual activation through mechanical cues. I will discuss the recent developments on adhesion GPCR signaling and introduce the receptor family as a topical area in neuroscience, immunology and cancer research.
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